OR6C1 Olfactory Receptor
| Gene Symbol | OR6C11 (View this gene in GeneCards) |
| Family | 6 |
| Subfamily | C |
| Pseudogene | No |
| CORP pseudogene probability score | |
| Aliases | OST267, HsOR12.5.11, ORL3815 |
| External Ids | HGNC: 8355 GeneBank: AF399506, NM_001005182 ORDB: ORL3815 |
| Build #39 labels | OR6C1 |
| Chromosomal location | 12:55,320,600-55,321,535 (+) |
| Cluster | 12@56 |
| Synteny | CLIC#31 |
| Remarks |
Most Similar ORs in Humans (Paralogs)
| Symbol | Percent | Length |
|---|---|---|
| OR6C3 | 74.76% | 309 |
| OR6C75 | 71.1% | 308 |
| OR6C7P | 70.1% | 311 |
Most Similar ORs in other species (Orthologs)
| Specie | Symbol | Percent | Length |
|---|---|---|---|
| Dog | OR6C1L | 82% | 311 |
| Dog | OR6C1K | 81% | 311 |
| Dog | OR6C1MP | 80% | 311 |
| Mouse | Or6c1 | 85% | 311 |
| Mouse | Or6c1b | 84% | 311 |
| Rat | Or6c1i | 83% | 309 |
| Rat | Or6c1 | 83% | 309 |
| Rat | Or6c1h | 81% | 312 |
| Rat | Or6c1f-ps | 80% | 311 |
| Cow | OR6C1O | 81% | 310 |
| Cow | OR6C1Q | 81% | 310 |
| Cow | OR6C1N | 80% | 311 |
| Orang | OR6C3 | 73% | 309 |
| Horse | OR6C1T | 85% | 311 |
| Horse | OR6C1S | 84% | 311 |
| Horse | OR6C1U | 82% | 311 |
| Chimp | OR6C74 | 67% | 310 |
Expression evidences
| Source | Accession |
|---|---|
| mRNA | BC136965 |
Sequence information
| Nucleotide sequence |
ATGAGAAACCATACAGAAATAACAGAGTTTATTCTTCTGGGATTAACAGATGACCCAAAT TTTCAGGTTGTAATCTTTGTCTTCCTGCTCATCACCTACATGCTCAGCATCACTGGGAAC CTGACCCTTATCACAATTACCCTGCTGGATTCCCACCTGCAGACCCCCATGTATTTCTTC CTCAGAAATTTCTCCATATTAGAAATTTCGTTCACAACCGTCAGTATACCCAAGTTTCTG GGTAACATTATTTCAGGAGATAAAACCATTTCCTTTAATAATTGCATAGTTCAGTTATTT TTCTTCATTCTCTTGGGAGTCACAGAGTTTTACCTTCTGGCTGCCATGTCCTATGACCGC TATGTGGCCATCTGCAAGCCTCTGCATTGCTTGAGTATCATGAATCGAAGAGTCTGCACA CTGCTTGTTTTTACTTCTTGGCTGGTTTCATTCTTAATCATATTCCCAGCACTCATGTTG CTTTTAAAGCTTCATTACTGTAGGTCTAATATTATTGACCATTTTACCTGTGATTATTTT CCACTGCTGCAACTTGCTTGTTCAGACACAAAATTCTTAGAGGTGATGGGATTTTCTTGT GCTGCGTTTACTCTAATGTTCACTTTGGCATTAATATTTCTGTCCTACATATACATTATC AGAACAATTTTGAGAATTCCTTCTACTAGTCAGAGGACAAAGGCCTTTTCCACATGTTCT TCCCACATGGTTGTTGTCTCCATCTCTTATGGCAGCTGCATTTTTATGTACATTAAACCC TCAGCAAAAGATAGAGTGTCCTTGAGCAAGGGAGTGGCAATACTAAACACCTCAGTAGCC CCCATGATGAACCCCTTTATTTACAGCCTAAGAAATCAGCAAGTCAAGCAAGCTTTCATT AACATGGCAAGGAAGACTGTATTTTTCACAAGCACA |
| Conceptual translation |
MRNHTEITEFILLGLTDDPNFQVVIFVFLLITYMLSITGNLTLITITLLDSHLQTPMYFF LRNFSILEISFTTVSIPKFLGNIISGDKTISFNNCIVQLFFFILLGVTEFYLLAAMSYDR YVAICKPLHCLSIMNRRVCTLLVFTSWLVSFLIIFPALMLLLKLHYCRSNIIDHFTCDYF PLLQLACSDTKFLEVMGFSCAAFTLMFTLALIFLSYIYIIRTILRIPSTSQRTKAFSTCS SHMVVVSISYGSCIFMYIKPSAKDRVSLSKGVAILNTSVAPMMNPFIYSLRNQQVKQAFI NMARKTVFFTST Protein domains and features |
Variations - SNPs
| Chr | Start | End | Type | Variation | AA Change | SNP IDs |
|---|---|---|---|---|---|---|
| 12 | 100 | -100 | NS | G/A | V/I | 1000GP (YRI, YRI, YRI, YRI, YRI, YRI, YRI, YRI) |
| 12 | 55,320,988 | 55,320,988 | NS | G/A | C/Y | 1000GP (CEU, CHBJPT) |
| 12 | 55,321,092 | 55,321,092 | NS | C/G | H/D | 1000GP (CEU, CHBJPT) |
| 12 | 55,321,264 | 55,321,264 | NS | C/T | T/I | 1000GP (CEU) |
| 12 | 55,321,335 | 55,321,335 | NS | G/A | V/I | 1000GP (CEU, CHBJPT) |
| 12 | 55,714,407 | 55,714,406 | Ins(1) | -/A | rs5798345 (DbSNP) | |
| 12 | 55,714,408 | 55,714,407 | Ins(1) | -/A | rs35291292 (DbSNP) | |
| 12 | 55,714,772 | 55,714,772 | NS | A/G | Y/C | rs7132431 (DbSNP) |
| 12 | 55,714,876 | 55,714,876 | NS | C/G | H/D | rs7132347 (DbSNP) |
| 12 | 55,715,048 | 55,715,048 | NS | C/T | T/I | rs7132600 (DbSNP) |
| 12 | 55,715,119 | 55,715,119 | NS | A/G | I/V | rs7132916 (DbSNP) |
Variations - CNVs
| Chr | Start | End | Type | Sources |
|---|---|---|---|---|
| 12 | 55,709,667 | 55,725,440 | CopyNumber | Variation_0429 (DGV) |
| 12 | 55,714,284 | 55,717,319 | CopyNumber | #88 (Waszak) |
| 12 | 55,714,876 | 55,725,690 | CopyNumber | Variation_1912 (DGV) |
Haplotypes
Protein haplotypes were calculated using the 1000 genomes project as described in Olender T. et. al. BMC Genomics 2012.
| V74I | C130Y | L161F | H165D | C200S | T222I | M243T | V246I | R291K | S311R | % Freq | CORP | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | V | Y | L | D | C | T | M | I | R | S | 63.44 | 0.212 |
| 2 | V | C | L | H | C | T | M | V | R | S | 18.82 | 1.000 |
| 3 | V | Y | L | D | C | I | M | I | R | S | 13.13 | 0.212 |
| 4 | V | Y | L | D | C | T | M | I | R | R | 1.61 | 0.212 |
| 5 | I | Y | L | D | C | T | M | I | R | S | 1.00 | 0.212 |
| 6 | I | Y | F | D | C | T | M | I | K | S | 0.54 | 0.212 |
| 7 | V | C | L | D | C | T | M | I | R | S | 0.46 | 1.000 |
| 8 | V | C | L | H | C | T | M | I | R | S | 0.46 | 1.000 |
| 9 | V | Y | L | D | C | T | M | V | R | S | 0.23 | 0.128 |
| 10 | V | Y | L | D | S | T | M | I | R | S | 0.15 | 0.212 |
| 11 | V | C | L | H | C | T | T | V | R | S | 0.08 | 1.000 |
| 12 | V | C | L | D | C | I | M | I | R | S | 0.08 | 1.000 |
AceView Gene Models
The information is based on AceView gene models, constructed from cDNA sequences. The information might be incomplete.
| Accession | Type | Chr | Start | End | Strand | |
|---|---|---|---|---|---|---|
| OR6C1.aApr07-unspliced | main_exon | CDS | chr12 | 55,320,600 | 55,321,535 | + |
| 3UTR | chr12 | 55,321,535 | 55,321,538 | + | ||