OR6C70 Olfactory Receptor
| Gene Symbol | OR6C701 (View this gene in GeneCards) |
| Family | 6 |
| Subfamily | C |
| Pseudogene | No |
| CORP pseudogene probability score | 0.46 (functional) |
| Aliases | HsOR12.5.20 |
| External Ids | HGNC: 31299 GeneBank: NM_001005499 |
| Build #39 labels | |
| Chromosomal location | 12:55,469,203-55,470,138 (-) |
| Cluster | 12@56 |
| Synteny | CLIC#31 |
| Remarks |
Most Similar ORs in Humans (Paralogs)
| Symbol | Percent | Length |
|---|---|---|
| OR6C6 | 74.75% | 305 |
| OR6C75 | 69.87% | 312 |
| OR6C76 | 71.57% | 306 |
Most Similar ORs in other species (Orthologs)
| Specie | Symbol | Percent | Length |
|---|---|---|---|
| Dog | OR6C75C | 70% | 310 |
| Mouse | Or6c70 | 80% | 310 |
| Rat | Or6c70 | 81% | 312 |
| Cow | OR6C272P | 82% | 312 |
| Cow | OR6C270P | 81% | 311 |
| Orang | OR6C76P | 71% | 307 |
| Horse | OR6C333P | 74% | 312 |
| Chimp | OR6C6 | 74% | 312 |
Expression evidences
| Source | Accession |
|---|---|
| GNF Atlas2 | gnf1h10941_at |
Sequence information
| Nucleotide sequence |
ATGAAGAATCATACAAGGCAGATAGAATTTATTCTTCTGGGACTGACGGATAATTCTCAG TTACAGATTGTAATTTTCTTATTTCTACTTCTAAATTGTGTGTTGAGCATGATAGGGAAC TTCACTATCATTGCCCTCATTCTGCTGGATTCCCAGCTCAAGACTCCAATGTATTTCTTC CTCCGTAATTTCTCTTTTCTGGAAATTTCATTCACAACTGCTTGCATTCCCAGATTCCTA ATCACCATTGTTACCAGGGAAAAGACCATTTCCTGTAATGGTTGCATATCTCAGTTGTTT TTTTACATATTCTTGGGGGTTACAGAATTTTTCCTTCTAGCTGCTCTGTCCTATGATCGC TATGTTGCCATCTGCAAACCTTTGCGTTATATGTCCATCATGAGTAACAAAGTTTGCTAC CAGCTTGTATTCAGTTCTTGGGTAACTGGATTCCTGATCATTTTCACTCCACTGATTTTA GGTCTTAACTTGGATTTCTGTGCTTCAAATATCATTGATCATTTCATTTGTGACATTTCT CTTATCCTACAACTTTCTTGCTCAGACACACATTTACTGGAACTGATTGCCTTTTTATTA GCTGTGATGACACTTATTGTCACATTGTTTTTAGTAATCCTTTCTTACTCTTACATCATC AAGACAATTCTGAAATTCCCTTCAGCTCAGCAAAAGAAGAAAGCCTTTTCCACCTGCTCT TCTCACATGATTGTTGTCTCCATCACTTATGGTAGTTGTATGTTTATCTACATAAAGCCA TCAGCGAATGAAAGAGTTGCTTTAAGCAAAGGAGTAACTGTGCTCAATACTTCAGTTGCC CCGTTGTTAAACCCATTTATTTATACTCTGAGGAATCAGCAAGTTAAACAAGCCTTCAAA GCTGTATTTAGAAAGATATTTTCTGCTTCAGACAAG |
| Conceptual translation |
MKNHTRQIEFILLGLTDNSQLQIVIFLFLLLNCVLSMIGNFTIIALILLDSQLKTPMYFF LRNFSFLEISFTTACIPRFLITIVTREKTISCNGCISQLFFYIFLGVTEFFLLAALSYDR YVAICKPLRYMSIMSNKVCYQLVFSSWVTGFLIIFTPLILGLNLDFCASNIIDHFICDIS LILQLSCSDTHLLELIAFLLAVMTLIVTLFLVILSYSYIIKTILKFPSAQQKKKAFSTCS SHMIVVSITYGSCMFIYIKPSANERVALSKGVTVLNTSVAPLLNPFIYTLRNQQVKQAFK AVFRKIFSASDK Protein domains and features |
Variations - SNPs
| Chr | Start | End | Type | Variation | AA Change | SNP IDs |
|---|---|---|---|---|---|---|
| 12 | 55,863,453 | 55,863,453 | NS | A/G | L/P | rs56038718 (DbSNP) |
| 12 | 55,863,381 | 55,863,381 | NS | A/G | L/P | rs10747756 (DbSNP) |
| 12 | 55,862,990 | 55,862,990 | NS | C/G | E/D | rs7295538 (DbSNP) |
| 12 | 55,863,224 | 55,863,224 | NS | C/G | K/N | rs60683621 (DbSNP) |
| 12 | 55,863,537 | 55,863,537 | NS | C/T | R/H | rs58920821 (DbSNP) |
| 12 | 55,863,398 | 55,863,398 | SYN | A/G | F/F | rs12313730 (DbSNP) |
| 12 | 55,469,614 | 55,469,614 | SYN | G/A | F/F | 1000GP (CEU, CHBJPT) |
| 12 | 55,469,440 | 55,469,440 | NS | C/G | K/N | 1000GP (CEU, CHBJPT) |
| 12 | 55,469,597 | 55,469,597 | NS | A/G | L/P | 1000GP (CEU, CHBJPT) |
| 12 | 55,469,398 | 55,469,398 | SYN | G/C | S/S | 1000GP (CHBJPT) |
| 12 | 55,469,753 | 55,469,753 | NS | C/T | R/H | 1000GP (CHBJPT) |
| 12 | 100 | -100 | NS | G/C | D/E | 1000GP (YRI, YRI, YRI) |
| 12 | 100 | -100 | SYN | G/A | L/L | 1000GP (YRI) |
Variations - CNVs
| Chr | Start | End | Type | Sources |
|---|---|---|---|---|
| 12 | 55,863,381 | 55,864,826 | CopyNumber | Variation_1501 (DGV) |
| 12 | 55,832,210 | 56,001,052 | CopyNumber | Variation_4780 (DGV) |
| CopyNumber | 179 (Hasin) | |||
| 12 | 55,860,987 | 55,864,022 | CopyNumber | #128 (Waszak) |
Haplotypes
Protein haplotypes were calculated using the 1000 genomes project as described in Olender T. et. al. BMC Genomics 2012.
| D311E | K233N | V212A | L181P | I171V | Q141* | C139S | R129H | R120H | A114S | T73A | % Freq | CORP | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | D | K | V | P | I | Q | C | R | R | A | T | 53.15 | 0.671 |
| 2 | D | N | V | P | I | Q | C | R | R | A | T | 25.04 | 0.671 |
| 3 | D | K | V | L | I | Q | C | R | R | A | T | 15.44 | 0.671 |
| 4 | D | K | V | P | I | Q | C | H | R | A | T | 2.00 | 0.671 |
| 5 | E | K | V | P | I | Q | C | R | R | A | T | 1.54 | 0.671 |
| 6 | D | N | V | P | I | Q | C | R | R | S | T | 1.08 | 0.671 |
| 7 | D | K | V | P | I | Q | C | R | R | A | A | 1.00 | 0.671 |
| 8 | D | K | V | P | I | Q | S | R | R | A | T | 0.23 | 0.671 |
| 9 | D | K | V | P | I | * | C | R | R | A | T | 0.15 | 1.200 |
| 10 | D | K | V | P | I | Q | C | H | H | A | T | 0.08 | 0.973 |
| 11 | D | N | V | L | I | Q | C | R | R | A | T | 0.08 | 0.671 |
| 12 | D | N | V | P | I | Q | C | R | H | A | T | 0.08 | 0.973 |
| 13 | D | N | V | P | V | Q | C | R | R | A | T | 0.08 | 0.671 |
| 14 | D | K | A | P | I | Q | C | R | R | A | T | 0.08 | 0.671 |
AceView Gene Models
The information is based on AceView gene models, constructed from cDNA sequences. The information might be incomplete.
| Accession | Type | Chr | Start | End | Strand | |
|---|---|---|---|---|---|---|
| OR6C70.aApr07-unspliced | main_exon | 3UTR | chr12 | 55,469,200 | 55,469,203 | - |
| CDS | chr12 | 55,469,203 | 55,470,138 | - | ||