OR6S1 Olfactory Receptor
| Gene Symbol | OR6S11 (View this gene in GeneCards) |
| Family | 6 |
| Subfamily | S |
| Pseudogene | No |
| CORP pseudogene probability score | 0.07 (functional) |
| Aliases | OR14-37, HsOR14.1.30, ORL3694 |
| External Ids | HGNC: 15363 GeneBank: AB065561, BK004263, NM_001001968 ORDB: ORL3694 |
| Build #39 labels | OR6S1 |
| Chromosomal location | 14:20,640,699-20,641,691 (-) |
| Cluster | 14@21 |
| Synteny | CLIC#33 |
| Remarks |
Most Similar ORs in Humans (Paralogs)
| Symbol | Percent | Length |
|---|---|---|
| OR6J1 | 51.47% | 307 |
| OR6M1 | 51.97% | 304 |
| OR6M2P | 50.97% | 310 |
Most Similar ORs in other species (Orthologs)
| Specie | Symbol | Percent | Length |
|---|---|---|---|
| Dog | OR6M2 | 53% | 310 |
| Mouse | Or6s1 | 84% | 328 |
| Rat | Or6s1 | 83% | 331 |
| Cow | OR6M2 | 54% | 310 |
| Orang | OR6S1P | 96% | 316 |
| Horse | OR6M2 | 54% | 310 |
| Chimp | OR6M1 | 52% | 309 |
Expression evidences
| Source | Accession |
|---|---|
| GNF Atlas2 | gnf1h02811_at |
Sequence information
| Nucleotide sequence |
ATGAGTCCTGATGGGAACCACAGTAGTGATCCAACAGAGTTCGTCCTGGCAGGGCTCCCA AATCTCAACAGCGCAAGAGTGGAATTATTTTCTGTGTTTCTTCTTGTCTATCTCCTGAAT CTGACAGGCAATGTGTTGATTGTGGGGGTGGTAAGGGCTGATACTCGACTACAGACCCCT ATGTACTTCTTTCTGGGTAACCTGTCCTGCCTAGAGATACTGCTCACTTCTGTCATCATT CCAAAGATGCTGAGCAATTTCCTCTCAAGGCAACACACTATTTCCTTTGCTGCATGTATC ACCCAATTCTATTTCTACTTCTTTCTCGGGGCCTCCGAGTTCTTACTGTTGGCTGTCATG TCTGCGGATCGCTACCTGGCCATCTGTCATCCTCTGCGCTACCCCTTGCTCATGAGTGGG GCTGTGTGCTTTCGTGTGGCCTTGGCCTGCTGGGTGGGGGGACTCGTCCCTGTGCTTGGT CCCACAGTGGCTGTGGCCTTGCTTCCTTTCTGTAAGCAGGGTGCTGTGGTACAGCACTTC TTCTGCGACAGTGGCCCACTGCTCCGCCTGGCTTGCACCAACACCAAGAAGCTGGAGGAG ACTGACTTTGTCCTGGCCTCCCTCGTCATTGTATCTTCCTTGCTGATCACTGCTGTGTCC TACGGCCTCATTGTGCTGGCAGTCCTGAGCATCCCCTCTGCTTCAGGCCGTCAGAAGGCC TTCTCTACCTGTACCTCCCACTTGATAGTGGTGACCCTCTTCTATGGAAGTGCCATTTTT CTCTATGTGCGGCCATCGCAGAGTGGTTCTGTGGACACTAACTGGGCAGTGACAGTAATA ACGACATTTGTGACACCACTGTTGAATCCATTCATCTATGCCTTACGTAATGAGCAAGTC AAGGAAGCTTTGAAGGACATGTTTAGGAAGGTAGTGGCAGGCGTTTTAGGGAATCTTTTA CTTGATAAATGTCTCAGTGAGAAAGCAGTAAAG |
| Conceptual translation |
MSPDGNHSSDPTEFVLAGLPNLNSARVELFSVFLLVYLLNLTGNVLIVGVVRADTRLQTP MYFFLGNLSCLEILLTSVIIPKMLSNFLSRQHTISFAACITQFYFYFFLGASEFLLLAVM SADRYLAICHPLRYPLLMSGAVCFRVALACWVGGLVPVLGPTVAVALLPFCKQGAVVQHF FCDSGPLLRLACTNTKKLEETDFVLASLVIVSSLLITAVSYGLIVLAVLSIPSASGRQKA FSTCTSHLIVVTLFYGSAIFLYVRPSQSGSVDTNWAVTVITTFVTPLLNPFIYALRNEQV KEALKDMFRKVVAGVLGNLLLDKCLSEKAVK Protein domains and features |
Variations - SNPs
| Chr | Start | End | Type | Variation | AA Change | SNP IDs |
|---|---|---|---|---|---|---|
| 14 | 21,109,726 | 21,109,726 | NS | A/G | I/T | rs11622794 (DbSNP) |
| 14 | 21,108,965 | 21,108,965 | NS | A/G | C/R | rs17114309 (DbSNP) |
| 14 | 21,109,745 | 21,109,745 | NS | C/G | V/L | rs45443395 (DbSNP) |
| 14 | 21,109,255 | 21,109,255 | NS | C/T | G/E | rs45592635 (DbSNP) |
| 14 | 21,109,141 | 21,109,141 | NS | C/T | R/H | rs17277522 (DbSNP) |
| 14 | 21,109,385 | 21,109,385 | NS | C/T | V/I | rs11622969 (DbSNP) |
| 14 | 21,109,505 | 21,109,505 | NS | G/T | L/M | rs72659934 (DbSNP) |
| 14 | 21,109,684 | 21,109,684 | NS | T/C | Q/R | rs61742423 (DbSNP) |
| 14 | 21,108,909 | 21,108,909 | SYN | A/G | G/G | rs17277515 (DbSNP) |
| 14 | 21,109,671 | 21,109,671 | SYN | A/G | P/P | rs11627574 (DbSNP) |
| 14 | 21,109,278 | 21,109,278 | SYN | A/T | A/A | rs11627438 (DbSNP) |
| 14 | 21,109,170 | 21,109,170 | SYN | A/T | A/A | rs11628297 (DbSNP) |
| 14 | 21,109,317 | 21,109,317 | SYN | T/C | Q/Q | rs61743445 (DbSNP) |
| 14 | 20,641,119 | 20,641,119 | SYN | A/T | A/A | 1000GP (CEU, CHBJPT) |
| 14 | 20,640,750 | 20,640,750 | SYN | G/A | G/G | 1000GP (CEU, CHBJPT) |
| 14 | 20,640,982 | 20,640,982 | NS | C/T | R/H | 1000GP (CEU, CHBJPT) |
| 14 | 20,641,567 | 20,641,567 | NS | G/A | T/I | 1000GP (CEU, CHBJPT) |
| 14 | 20,641,226 | 20,641,226 | NS | C/T | V/I | 1000GP (CEU, CHBJPT) |
| 14 | 20,641,586 | 20,641,586 | NS | C/G | V/L | 1000GP (CEU) |
| 14 | 20,641,512 | 20,641,512 | SYN | A/G | P/P | 1000GP (CEU, CHBJPT) |
| 14 | 100 | -100 | NS | G/T | L/I | 1000GP (YRI, YRI, YRI, YRI, YRI) |
| 14 | 100 | -100 | SYN | G/A | G/G | 1000GP (YRI, YRI, YRI, YRI, YRI) |
Variations - CNVs
| Chr | Start | End | Type | Sources |
|---|---|---|---|---|
| 14 | 20,800,765 | 21,257,878 | CopyNumber | Variation_71865 (DGV) |
| 14 | 21,106,858 | 21,109,950 | Deletion | #238 (Waszak) |
Haplotypes
Protein haplotypes were calculated using the 1000 genomes project as described in Olender T. et. al. BMC Genomics 2012.
| L319I | R296C | I280V | R237H | E199G | R189H | V176M | V156I | Y125H | L116M | L115S | T42I | V36L | % Freq | CORP | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | L | R | I | R | E | R | V | I | Y | L | L | I | V | 44.24 | 0.116 |
| 2 | L | R | I | H | E | R | V | V | Y | L | L | T | V | 44.01 | 0.098 |
| 3 | L | C | I | H | E | R | V | V | Y | L | L | T | V | 3.00 | 0.098 |
| 4 | L | R | I | H | E | R | V | V | Y | L | L | T | L | 2.46 | 0.098 |
| 5 | L | R | I | R | E | R | V | V | Y | L | L | T | V | 1.69 | 0.116 |
| 6 | L | R | I | H | E | R | V | V | Y | L | L | I | V | 1.31 | 0.098 |
| 7 | L | R | I | H | G | R | V | V | Y | L | L | T | V | 0.77 | 0.098 |
| 8 | L | R | I | H | E | R | V | V | Y | M | L | T | V | 0.54 | 0.228 |
| 9 | L | R | V | R | E | R | V | I | Y | L | L | I | V | 0.54 | 0.116 |
| 10 | L | R | I | H | E | R | V | V | H | L | L | T | V | 0.31 | 0.066 |
| 11 | L | R | I | R | E | R | V | V | Y | L | L | I | V | 0.31 | 0.116 |
| 12 | L | R | I | R | E | R | V | I | Y | L | L | T | V | 0.23 | 0.116 |
| 13 | I | R | I | R | E | R | V | I | Y | L | L | I | V | 0.23 | 0.116 |
| 14 | L | R | I | H | E | R | V | V | Y | L | S | T | V | 0.15 | 0.098 |
| 15 | L | R | I | H | E | R | M | V | Y | L | L | T | V | 0.08 | 0.098 |
| 16 | L | C | I | H | E | R | V | V | Y | L | L | T | L | 0.08 | 0.098 |
| 17 | L | R | I | H | E | H | V | V | Y | L | L | T | V | 0.08 | 0.098 |
AceView Gene Models
The information is based on AceView gene models, constructed from cDNA sequences. The information might be incomplete.
| Accession | Type | Chr | Start | End | Strand | |
|---|---|---|---|---|---|---|
| OR6S1.aApr07-unspliced | main_exon | 3UTR | chr14 | 20,640,696 | 20,640,699 | - |
| CDS | chr14 | 20,640,699 | 20,641,691 | - | ||