OR8A1 Olfactory Receptor
| Gene Symbol | OR8A11 (View this gene in GeneCards) |
| Family | 8 |
| Subfamily | A |
| Pseudogene | No |
| CORP pseudogene probability score | 0.1 (functional) |
| Aliases | OR11-318, OST025, HsOR11.18.42, ORL3332 |
| External Ids | HGNC: 8469 GeneBank: AB065833, AF399512, AY726592, BK004495, NM_001005194 ORDB: ORL3332 |
| Build #39 labels | OR8A1 |
| Chromosomal location | 11:124,570,120-124,571,046 (+) |
| Cluster | 11@124 |
| Synteny | CLIC#29 |
| Remarks |
Most Similar ORs in Humans (Paralogs)
| Symbol | Percent | Length |
|---|---|---|
| OR8A2P | 74.92% | 307 |
Most Similar ORs in other species (Orthologs)
| Specie | Symbol | Percent | Length |
|---|---|---|---|
| Dog | OR8G3 | 65% | 308 |
| Mouse | Or8a1b | 85% | 309 |
| Mouse | Or8a1-ps | 85% | 309 |
| Rat | Or8a1b | 87% | 309 |
| Rat | Or8a1 | 87% | 309 |
| Cow | OR8A1C | 86% | 308 |
| Cow | OR8A1D | 86% | 307 |
| Cow | OR8A1E | 84% | 309 |
| Orang | OR8A2P | 74% | 311 |
| Horse | OR8A1I | 88% | 309 |
| Horse | OR8A1J | 86% | 309 |
| Chimp | OR8A2P | 71% | 307 |
Expression evidences
| Source | Accession |
|---|---|
| ESTs | CR746755 |
| mRNA | AY726592 |
Sequence information
| Nucleotide sequence |
ATGGCTGCAGGAAATCACTCTACAGTGACAGAGTTCATTCTCAAGGGTTTAACGAAGAGA GCAGACCTCCAGCTCCCCCTCTTTCTCCTCTTCCTCGGGATCTACTTGGTCACCATCGTG GGGAACCTGGGCATGATCACTCTAATTTGTCTGAACTCTCAGCTGCACACCCCCATGTAC TACTTTCTCAGCAATCTGTCACTCATGGATCTCTGCTACTCCTCCGTCATTACCCCTAAG ATGCTGGTGAACTTTGTGTCAGAGAAAAACATCATCTCCTACGCAGGGTGCATGTCACAG CTCTACTTCTTCCTTGTTTTTGTCATTGCTGAGTGTTACATGCTGACAGTGATGGCCTAC GACCGCTATGTTGCCATCTGCCACCCTTTGCTTTACAACATCATTATGTCTCATCACACC TGCCTGCTGCTGGTGGCTGTGGTCTACGCCATCGGACTCATTGGCTCCACAATAGAAACT GGCCTCATGTTAAAACTGCCCTATTGTGAGCACCTCATCAGTCACTACTTCTGTGACATC CTCCCTCTCATGAAGCTGTCCTGCTCTAGCACCTATGATGTTGAGATGACAGTCTTCTTT TCGGCTGGATTCAACATCATAGTCACGAGCTTAACAGTTCTTGTTTCTTACACCTTCATT CTCTCCAGCATCCTCGGCATCAGCACCACAGAGGGGAGATCCAAAGCCTTCAGCACCTGC AGCTCCCACCTTGCAGCCGTGGGAATGTTCTATGGATCAACTGCATTCATGTACTTAAAA CCCTCCACAATCAGTTCCTTGACCCAGGAGAATGTGGCCTCTGTGTTCTACACCACGGTA ATCCCCATGTTGAATCCCCTAATCTACAGCCTGAGGAACAAGGAAGTAAAGGCTGCCGTG CAGAAAACGCTGAGGGGTAAACTGTTT |
| Conceptual translation |
MAAGNHSTVTEFILKGLTKRADLQLPLFLLFLGIYLVTIVGNLGMITLICLNSQLHTPMY YFLSNLSLMDLCYSSVITPKMLVNFVSEKNIISYAGCMSQLYFFLVFVIAECYMLTVMAY DRYVAICHPLLYNIIMSHHTCLLLVAVVYAIGLIGSTIETGLMLKLPYCEHLISHYFCDI LPLMKLSCSSTYDVEMTVFFSAGFNIIVTSLTVLVSYTFILSSILGISTTEGRSKAFSTC SSHLAAVGMFYGSTAFMYLKPSTISSLTQENVASVFYTTVIPMLNPLIYSLRNKEVKAAV QKTLRGKLF Protein domains and features |
Variations - SNPs
| Chr | Start | End | Type | Variation | AA Change | SNP IDs |
|---|---|---|---|---|---|---|
| 11 | 124,440,389 | 124,440,389 | NS | A/C | D/A | rs61750763 (DbSNP) |
| 11 | 124,440,241 | 124,440,241 | NS | A/G | I/V | rs61756691 (DbSNP) |
| 11 | 124,440,043 | 124,440,043 | NS | A/G | T/A | rs7927196 (DbSNP) |
| 11 | 124,440,362 | 124,440,362 | NS | C/G | T/R | rs55861866 (DbSNP) |
| 11 | 124,440,617 | 124,440,617 | NS | C/T | S/L | rs12792184 (DbSNP) |
| 11 | 124,440,923 | 124,440,923 | NS | C/T | T/M | rs59034440 (DbSNP) |
| 11 | 124,440,078 | 124,440,078 | SYN | A/G | A/A | rs61748615 (DbSNP) |
| 11 | 124,440,297 | 124,440,297 | SYN | C/T | Y/Y | rs61748716 (DbSNP) |
| 11 | 124,440,132 | 124,440,132 | SYN | C/T | I/I | rs61753590 (DbSNP) |
| 11 | 124,570,721 | 124,570,721 | NS | C/T | S/L | 1000GP (CEU, CHBJPT) |
| 11 | 124,570,466 | 124,570,466 | NS | C/G | T/R | 1000GP (CEU, CHBJPT) |
| 11 | 100 | -100 | SYN | C/T | I/I | 1000GP (YRI) |
| 11 | 100 | -100 | NS | G/A | V/I | 1000GP (YRI, YRI, YRI, YRI, YRI) |
Variations - CNVs
| Chr | Start | End | Type | Sources |
|---|---|---|---|---|
| CopyNumber | 135 (Hasin) | |||
| 11 | 124,439,916 | 124,442,942 | CopyNumber | #84 (Waszak) |
Haplotypes
Protein haplotypes were calculated using the 1000 genomes project as described in Olender T. et. al. BMC Genomics 2012.
| T27A | V93I | K97E | T133R | A142D | V317M | T320M | % Freq | CORP | |
|---|---|---|---|---|---|---|---|---|---|
| 1 | T | V | K | T | A | V | T | 67.59 | 0.972 |
| 2 | T | V | K | R | A | V | T | 27.50 | 0.972 |
| 3 | T | V | K | T | A | V | M | 1.46 | 0.972 |
| 4 | T | I | K | T | A | V | T | 1.38 | 0.972 |
| 5 | T | V | K | T | A | M | T | 1.00 | 0.972 |
| 6 | A | V | K | T | A | V | T | 0.77 | 0.972 |
| 7 | T | V | E | T | A | V | M | 0.15 | 0.972 |
| 8 | A | V | K | T | A | V | M | 0.08 | 0.972 |
| 9 | T | V | K | T | D | V | T | 0.08 | 0.972 |
AceView Gene Models
The information is based on AceView gene models, constructed from cDNA sequences. The information might be incomplete.
| Accession | Type | Chr | Start | End | Strand | |
|---|---|---|---|---|---|---|
| OR8A1.aApr07-unspliced | main_exon | 5UTR | chr11 | 124,570,069 | 124,570,120 | + |
| CDS | chr11 | 124,570,120 | 124,571,046 | + | ||
| 3UTR | chr11 | 124,571,046 | 124,571,372 | + | ||
| OR8A1.bApr07 | main_exon | CDS_partial | chr11 | 124,570,193 | 124,571,035 | + |
| exon_3UTR | chr11 | 124,578,049 | 124,578,289 | + | ||
| exon_3UTR | chr11 | 124,582,909 | 124,582,942 | + | ||