OR8B12 Olfactory Receptor
| Gene Symbol | OR8B121 (View this gene in GeneCards) |
| Family | 8 |
| Subfamily | B |
| Pseudogene | No |
| CORP pseudogene probability score | 0.04 (functional) |
| Aliases | OR11-317, HsOR11.18.41, ORL3333 |
| External Ids | HGNC: 15307 GeneBank: AB065834, AF399511, BK004494, NM_001005195 ORDB: ORL3333 |
| Build #39 labels | OR8B12 |
| Chromosomal location | 11:124,542,725-124,543,654 (-) |
| Cluster | 11@124 |
| Synteny | CLIC#29 |
| Remarks |
Most Similar ORs in Humans (Paralogs)
| Symbol | Percent | Length |
|---|---|---|
| OR8B10P | 80.39% | 311 |
| OR8B8 | 80.06% | 311 |
| OR8B9P | 80.06% | 311 |
Most Similar ORs in other species (Orthologs)
| Specie | Symbol | Percent | Length |
|---|---|---|---|
| Dog | OR8B8 | 82% | 310 |
| Dog | OR8B9 | 81% | 311 |
| Dog | OR8B9B | 82% | 287 |
| Mouse | Or8b12 | 85% | 310 |
| Mouse | Or8b12b | 84% | 310 |
| Mouse | Or8b8 | 84% | 310 |
| Mouse | Or8b12c | 83% | 310 |
| Rat | Or8b12 | 86% | 310 |
| Rat | Or8b12d | 85% | 310 |
| Rat | Or8b8 | 83% | 310 |
| Cow | OR8B9 | 82% | 311 |
| Cow | OR8B9C | 81% | 311 |
| Cow | OR8B8 | 80% | 310 |
| Orang | OR8B10 | 83% | 311 |
| Orang | OR8B8 | 80% | 311 |
| Horse | OR8B12E | 84% | 310 |
| Chimp | OR8B12P | 97% | 310 |
Expression evidences
| Source | Accession |
|---|---|
| mRNA | BC136864 |
Sequence information
| Nucleotide sequence |
ATGGCAGCCAAAAACTCTTCTGTGACAGAGTTTATCCTCGAAGGCTTAACCCACCAGCCG GGACTGCGGATCCCCCTCTTCTTCCTGTTTCTGGGTTTCTACACGGTCACCGTGGTGGGG AACCTGGGCTTGATAACCCTGATTGGGCTGAACTCTCACCTGCACACTCCCATGTACTTC TTCCTTTTTAACCTCTCTTTAATAGATTTCTGTTTCTCCACTACCATCACTCCCAAAATG CTGATGAGTTTTGTCTCAAGGAAGAACATCATTTCCTTCACAGGGTGTATGACTCAGCTC TTCTTCTTCTGCTTCTTTGTCGTCTCTGAGTCCTTCATCCTGTCAGCGATGGCGTATGAC CGCTACGTGGCCATCTGTAACCCACTGTTGTACACAGTCACCATGTCTTGCCAGGTGTGT TTGCTCCTTTTGTTGGGTGCCTATGGGATGGGGTTTGCTGGGGCCATGGCCCACACAGGA AGCATAATGAACCTGACCTTCTGTGCTGACAACCTTGTCAATCATTTCATGTGTGACATC CTTCCTCTCCTTGAGCTCTCCTGCAACAGCTCTTACATGAATGAGCTGGTGGTCTTTATT GTGGTGGCTGTTGACGTTGGAATGCCCATTGTCACTGTCTTTATTTCTTATGCCCTCATC CTCTCCAGCATTCTACACAACAGTTCTACAGAAGGCAGGTCCAAAGCCTTTAGTACTTGC AGTTCCCACATAATTGTAGTTTCTCTTTTCTTTGGTTCTGGTGCTTTCATGTATCTCAAA CCCCTTTCCATCCTGCCCCTCGAGCAAGGGAAAGTGTCCTCCCTGTTCTATACCATAATA GTCCCCGTGTTAAACCCATTAATCTATAGCTTGAGGAACAAGGATGTCAAAGTTGCCCTG AGGAGAACTTTGGGCAGAAAAATCTTTTCT |
| Conceptual translation |
MAAKNSSVTEFILEGLTHQPGLRIPLFFLFLGFYTVTVVGNLGLITLIGLNSHLHTPMYF FLFNLSLIDFCFSTTITPKMLMSFVSRKNIISFTGCMTQLFFFCFFVVSESFILSAMAYD RYVAICNPLLYTVTMSCQVCLLLLLGAYGMGFAGAMAHTGSIMNLTFCADNLVNHFMCDI LPLLELSCNSSYMNELVVFIVVAVDVGMPIVTVFISYALILSSILHNSSTEGRSKAFSTC SSHIIVVSLFFGSGAFMYLKPLSILPLEQGKVSSLFYTIIVPVLNPLIYSLRNKDVKVAL RRTLGRKIFS Protein domains and features |
Variations - SNPs
| Chr | Start | End | Type | Variation | AA Change | SNP IDs |
|---|---|---|---|---|---|---|
| 11 | 124,412,860 | 124,412,859 | Ins(1) | -/A | rs34165015 (DbSNP) | |
| 11 | 124,413,261 | 124,413,261 | NS | A/T | M/K | rs61743861 (DbSNP) |
| 11 | 124,412,730 | 124,412,730 | NS | G/A | S/F | rs61745407 (DbSNP) |
| 11 | 124,412,838 | 124,412,838 | NS | T/C | N/S | rs61747005 (DbSNP) |
| 11 | 124,413,248 | 124,413,248 | SYN | G/A | F/F | rs61743599 (DbSNP) |
| 11 | 124,413,491 | 124,413,491 | SYN | T/C | P/P | rs61746453 (DbSNP) |
| 11 | 124,412,747 | 124,412,747 | SYN | T/C | E/E | rs61745404 (DbSNP) |
| 11 | 124,542,942 | 124,542,942 | NS | C/T | S/N | 1000GP (CEU) |
| 11 | 100 | -100 | NS | G/A | S/F | 1000GP (YRI, YRI, YRI) |
| 11 | 100 | -100 | SYN | C/T | E/E | 1000GP (YRI, YRI, YRI) |
| 11 | 100 | -100 | nonsense SNP | A/C | Y/* | 1000GP (YRI) |
Haplotypes
Protein haplotypes were calculated using the 1000 genomes project as described in Olender T. et. al. BMC Genomics 2012.
| S274F | S238N | M97K | % Freq | CORP | |
|---|---|---|---|---|---|
| 1 | S | S | M | 91.55 | 0.116 |
| 2 | S | N | M | 4.99 | 0.171 |
| 3 | F | S | M | 2.15 | 0.116 |
| 4 | S | S | K | 1.31 | 0.116 |
AceView Gene Models
The information is based on AceView gene models, constructed from cDNA sequences. The information might be incomplete.
| Accession | Type | Chr | Start | End | Strand | |
|---|---|---|---|---|---|---|
| OR8B12.aApr07-unspliced | main_exon | 3UTR | chr11 | 124,542,722 | 124,542,725 | - |
| CDS | chr11 | 124,542,725 | 124,543,654 | - | ||