OR1F1 Olfactory Receptor
| Gene Symbol | OR1F11 (View this gene in GeneCards) |
| Family | 1 |
| Subfamily | F |
| Pseudogene | No |
| CORP pseudogene probability score | 0.36 (functional) |
| Aliases | OR16-35, OR16-36, OR16-37, OR16-4, OR3-145, OR16-90, OLFMF, OR16-88, OR16-89, HsOR16.1.1, ORL1023 |
| External Ids | HGNC: 8194 GeneBank: AB065907, AF399559, BC069335, BK004247, HSOLFMF, NM_012360, U86234-U86237, U86239 ORDB: ORL1023 |
| Build #39 labels | OR1F1, OR1F10, OR1F13P |
| Chromosomal location | 16:3,204,247-3,205,182 (+) |
| Cluster | 16@3 |
| Synteny | CLIC#38 |
| Remarks | Segregating Pseudo Gene, a nonsynonymous SNP in a highly conserved amino-acid (rs769427) |
Most Similar ORs in Humans (Paralogs)
| Symbol | Percent | Length |
|---|---|---|
| OR1F2P | 81.31% | 305 |
Most Similar ORs in other species (Orthologs)
| Specie | Symbol | Percent | Length |
|---|---|---|---|
| Dog | OR1F1P | 79% | 306 |
| Mouse | Or1f19 | 74% | 306 |
| Rat | Or1f33 | 80% | 312 |
| Cow | OR1F1BP | 84% | 305 |
| Cow | OR1F1C | 83% | 279 |
| Orang | OR1F2 | 81% | 312 |
| Horse | OR1F1D | 83% | 311 |
| Chimp | OR1F1P | 96% | 303 |
Expression evidences
| Source | Accession |
|---|---|
| mRNA | Y14442 |
| GNF Atlas2 | 221402_at |
Sequence information
| Nucleotide sequence |
ATGAGCGGGACAAACCAGTCGAGTGTCTCCGAGTTCCTCCTCCTGGGACTCTCCAGGCAG CCCCAGCAGCAGCATCTCCTCTTTGTGTTCTTCCTCAGCATGTACCTGGCCACTGTCCTG GGGAACCTGCTCATCATCCTGTCCGTAAGCATAGACTCCTGCCTGCACACCCCCATGTAC TTCTTCCTCAGCAACCTGTCTTTTGTGGACATCTGCTTCTCCTTCACCACCGTCCCCAAG ATGCTGGCCAATCACATACTCGAGACTCAGACCATCTCCTTCTGTGGCTGTCTCACACAG ATGTATTTCGTTTTCATGTTCGTGGACATGGACAATTTCCTCCTAGCTGTGATGGCCTAT GACCACTTTGTCGCCGTGTGCCACCCCTTACATTACACAGCAAAGATGACCCATCAGCTC TGTGCCCTGCTGGTTGCTGGATTATGGGTGGTTGCCAACCTGAATGTCCTTCTGCACACC CTGCTGATGGCTCCACTCTCATTCTGTGCAGACAATGCCATCACTCACTTCTTCTGCGAT GTGACTCCCCTACTGAAACTCTCCTGCTCAGACACACACCTCAATGAGGTCATAATCCTT AGTGAGGGTGCCCTGGTCATGATCACCCCATTTCTTTGCATCCTGGCTTCTTATATGCAC ATCACCTGCACTGTCCTGAAGGTCCCATCCACAAAGGGAAGGTGGAAAGCCTTCTCCACC TGTGGTTCTCACCTGGCTGTGGTTCTCCTCTTCTACAGCACCATCATTGCTGTGTATTTT AACCCTCTGTCCTCCCACTCAGCTGAGAAAGACACTATGGCTACTGTGTTGTATACAGTA GTGACTCCCATGCTAAACCCTTTCATCTACAGCCTGAGGAACAGGTACTTGAAAGGGGCT CTGAAAAAAGTAGTTGGCAGGGTGGTGTTTTCTGTC |
| Conceptual translation |
MSGTNQSSVSEFLLLGLSRQPQQQHLLFVFFLSMYLATVLGNLLIILSVSIDSCLHTPMY FFLSNLSFVDICFSFTTVPKMLANHILETQTISFCGCLTQMYFVFMFVDMDNFLLAVMAY DHFVAVCHPLHYTAKMTHQLCALLVAGLWVVANLNVLLHTLLMAPLSFCADNAITHFFCD VTPLLKLSCSDTHLNEVIILSEGALVMITPFLCILASYMHITCTVLKVPSTKGRWKAFST CGSHLAVVLLFYSTIIAVYFNPLSSHSAEKDTMATVLYTVVTPMLNPFIYSLRNRYLKGA LKKVVGRVVFSV Protein domains and features |
Variations - SNPs
| Chr | Start | End | Type | Variation | AA Change | SNP IDs |
|---|---|---|---|---|---|---|
| 16 | 100 | -100 | NS | T/C | Y/H | 1000GP (YRI, YRI, YRI, YRI, YRI) |
| 16 | 100 | -100 | SYN | C/T | S/S | 1000GP (YRI, YRI) |
| 16 | 3,204,418 | 3,204,418 | NS | C/G | P/A | 1000GP (CEU) |
| 16 | 3,204,470 | 3,204,470 | NS | T/C | F/S | 1000GP (CEU, CHBJPT) |
| 16 | 3,204,972 | 3,204,972 | SYN | T/C | G/G | 1000GP (CEU, CHBJPT) |
| 16 | 3,254,418 | 3,254,418 | NS | C/G | P/A | rs61731432 (DbSNP) |
| 16 | 3,254,424 | 3,254,424 | NS | C/T | H/Y | rs61731433 (DbSNP) |
| 16 | 3,254,428 | 3,254,428 | NS | C/T | S/F | rs61731434 (DbSNP) |
| 16 | 3,254,470 | 3,254,470 | NS | T/C | F/S | rs1834026 (DbSNP) |
| 16 | 3,254,566 | 3,254,566 | NS | C/T | S/F | rs61731435 (DbSNP) |
| 16 | 3,254,611 | 3,254,611 | NS | A/G | H/R | rs61731440 (DbSNP) |
| 16 | 3,254,622 | 3,254,622 | NS | A/G | M/V | rs8045183 (DbSNP) |
| 16 | 3,254,783 | 3,254,783 | NS | C/G | C/W | rs61731438 (DbSNP) |
| 16 | 3,254,972 | 3,254,972 | SYN | C/T | G/G | rs2075851 (DbSNP) |
Variations - CNVs
| Chr | Start | End | Type | Sources |
|---|---|---|---|---|
| 16 | 3,202,782 | 3,309,413 | CopyNumber | Variation_4921 (DGV) |
| 16 | 3,254,147 | 3,257,182 | CopyNumber | #95 (Waszak) |
Haplotypes
Protein haplotypes were calculated using the 1000 genomes project as described in Olender T. et. al. BMC Genomics 2012.
| L14F | P58A | Y60H | F75S | E88K | H122R | V126M | C179W | T209N | % Freq | CORP | |
|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | L | P | Y | F | E | H | V | C | T | 54.22 | 0.602 |
| 2 | L | P | Y | S | E | H | V | C | T | 38.40 | 0.602 |
| 3 | L | P | Y | S | E | H | M | C | T | 3.53 | 0.936 |
| 4 | L | A | Y | S | E | H | V | C | T | 1.23 | 0.763 |
| 5 | L | P | Y | F | E | R | V | C | T | 1.23 | 0.078 |
| 6 | L | P | H | F | E | H | V | C | T | 0.77 | 0.958 |
| 7 | L | P | Y | S | E | H | V | C | N | 0.23 | 0.602 |
| 8 | L | P | H | F | E | R | V | C | T | 0.15 | 0.562 |
| 9 | F | P | Y | F | E | H | V | C | T | 0.08 | 0.602 |
| 10 | L | P | Y | F | E | H | V | W | T | 0.08 | 0.865 |
| 11 | L | P | Y | F | K | H | V | C | T | 0.08 | 0.602 |
AceView Gene Models
The information is based on AceView gene models, constructed from cDNA sequences. The information might be incomplete.
| Accession | Type | Chr | Start | End | Strand | |
|---|---|---|---|---|---|---|
| OR1F1.aApr07-unspliced | main_exon | CDS | chr16 | 3,204,247 | 3,205,182 | + |
| 3UTR | chr16 | 3,205,182 | 3,205,188 | + | ||