OR2A5 Olfactory Receptor
| Gene Symbol | OR2A51 (View this gene in GeneCards) |
| Family | 2 |
| Subfamily | A |
| Pseudogene | No |
| CORP pseudogene probability score | 0.05 (functional) |
| Aliases | OR7-138, OR7-141, HsOR7.6.10, ORL396, ORL272 |
| External Ids | HGNC: 8232 GeneBank: AF399595, NM_012365, U86278, U86281 ORDB: ORL396, ORL272 |
| Build #39 labels | OR2A5, OR2A26 |
| Chromosomal location | 7:144,050,402-144,051,334 (+) |
| Cluster | 7@144 |
| Synteny | CLIC#16 |
| Remarks |
Most Similar ORs in Humans (Paralogs)
| Symbol | Percent | Length |
|---|---|---|
| OR2A20P | 80.84% | 308 |
| OR2A42 | 80.19% | 308 |
| OR2A9P | 80.84% | 308 |
Most Similar ORs in other species (Orthologs)
| Specie | Symbol | Percent | Length |
|---|---|---|---|
| Dog | OR2A14 | 81% | 309 |
| Mouse | Or2a5 | 87% | 311 |
| Rat | Or2a5 | 86% | 311 |
| Cow | OR2A14 | 81% | 309 |
| Orang | OR2A9 | 81% | 308 |
| Orang | OR2A14 | 80% | 309 |
| Orang | OR2A42 | 80% | 308 |
| Horse | OR2A9 | 81% | 308 |
| Chimp | OR2A42 | 81% | 308 |
Expression evidences
| Source | Accession |
|---|---|
| mRNA | BC136860 |
Sequence information
| Nucleotide sequence |
ATGACAAAAAATCAGACATGGGTCACAGAATTCATTCTCCTGGGATTTCCACTCAGCCTA AGGATTCAGATGCTCCTCTCTGGGCTTTTCTCCCTGTTATACGTCTTCACCCTGCTGGGA AATGGGGCCATCCTGGGGCTCATCTGGCTGGACTCCAGACTGCACACCCCCATGTACTTC TTTCTCTCACACCTGGCCATCATTGATATTTCGTATGCTTCCAACAATGTCCCCAAGATG CTGACAAACCTTGGCTTGAACAAGAGAAAAACAATCTCCTTTGTCCCATGCACAATGCAG ACCTTTTTATACATGGCTTTTGCTCACACTGAGTGTCTCATCTTGGTAATGATGTCCTAC GATCGGTACATGGCTATCTGCCACCCTCTGCAATATTCTGTCATCATGAGATGGGGAGTG TGCACAGTCCTGGCTGTCACTTCTTGGGCATGTGGTTCCCTTCTGGCCCTGGTCCATGTG GTTCTCATCCTGAGGCTGCCCTTCTGTGGGCCCCATGAAATCAACCACTTCTTCTGTGAA ATCCTGTCTGTCCTCAAGTTGGCCTGTGCTGACACCTGGCTCAACCAGGTGGTCATCTTT GCTGCTTCAGTGTTCATCCTGGTGGGGCCGCTCTGCCTGGTGCTGGTCTCCTACTCGCGC ATCCTGGCGGCCATCTTGAGGATCCAGTCTGGGGAGGGCCGCAGAAAGGCCTTCTCCACC TGCTCCTCCCACCTTTGCATGGTGGGACTCTTCTTTGGCAGCGCCATTGTCATGTACATG GCCCCCAAGTCCCGCCACCCTGAGGAGCAGCAGAAGGTCCTTTCCCTGTTTTACAGCCTT TTCAACCCGATGCTGAACCCCTTGATCTATAGCCTGAGGAACGCAGAGGTCAAGGGTGCC CTGAAAAGAGTGTTGTGGAAACAGAGATCAAAG |
| Conceptual translation |
MTKNQTWVTEFILLGFPLSLRIQMLLSGLFSLLYVFTLLGNGAILGLIWLDSRLHTPMYF FLSHLAIIDISYASNNVPKMLTNLGLNKRKTISFVPCTMQTFLYMAFAHTECLILVMMSY DRYMAICHPLQYSVIMRWGVCTVLAVTSWACGSLLALVHVVLILRLPFCGPHEINHFFCE ILSVLKLACADTWLNQVVIFAASVFILVGPLCLVLVSYSRILAAILRIQSGEGRRKAFST CSSHLCMVGLFFGSAIVMYMAPKSRHPEEQQKVLSLFYSLFNPMLNPLIYSLRNAEVKGA LKRVLWKQRSK Protein domains and features |
Variations - SNPs
| Chr | Start | End | Type | Variation | AA Change | SNP IDs |
|---|---|---|---|---|---|---|
| 7 | 143,747,952 | 143,747,952 | Del(1) | -/C | rs35952994 (DbSNP) | |
| 7 | 143,747,796 | 143,747,796 | NS | A/C | N/T | rs61741408 (DbSNP) |
| 7 | 143,748,257 | 143,748,257 | NS | A/G | T/A | rs6464574 (DbSNP) |
| 7 | 143,747,870 | 143,747,870 | NS | A/G | I/V | rs2961144 (DbSNP) |
| 7 | 143,747,524 | 143,747,524 | NS | A/T | E/D | rs61739955 (DbSNP) |
| 7 | 143,747,799 | 143,747,799 | NS | C/T | S/F | rs61741407 (DbSNP) |
| 7 | 143,748,098 | 143,748,098 | NS | G/T | A/S | rs6464573 (DbSNP) |
| 7 | 143,747,629 | 143,747,629 | SYN | A/G | L/L | rs61738793 (DbSNP) |
| 7 | 143,748,364 | 143,748,364 | SYN | C/T | Y/Y | rs4407791 (DbSNP) |
| 7 | 144,051,005 | 144,051,005 | NS | G/T | A/S | 1000GP (CEU) |
| 7 | 144,051,164 | 144,051,164 | NS | G/A | A/T | 1000GP (CEU) |
| 7 | 144,050,777 | 144,050,777 | NS | A/G | I/V | 1000GP (CEU) |
| 7 | 144,051,271 | 144,051,271 | SYN | T/C | Y/Y | 1000GP (CEU, CHBJPT) |
| 7 | 100 | -100 | NS | G/A | M/I | 1000GP (YRI, YRI, YRI, YRI, YRI, YRI, YRI) |
| 7 | 100 | -100 | SYN | G/A | L/L | 1000GP (YRI, YRI, YRI, YRI) |
Variations - CNVs
| Chr | Start | End | Type | Sources |
|---|---|---|---|---|
| 7 | 143,147,775 | 144,368,638 | CopyNumber | Variation_3708 (DGV) |
| 7 | 143,742,520 | 143,847,474 | CopyNumber | Variation_4570 (DGV) |
| 7 | 143,572,286 | 143,866,532 | CopyNumber | Variation_8581 (DGV) |
| 7 | 143,217,296 | 144,074,520 | CopyNumber | Variation_32962 (DGV) |
| 7 | 143,545,719 | 143,874,190 | CopyNumber | Variation_53583 (DGV) |
| 7 | 143,747,395 | 143,750,427 | Deletion | #194 (Waszak) |
Haplotypes
Protein haplotypes were calculated using the 1000 genomes project as described in Olender T. et. al. BMC Genomics 2012.
| M1I | E10D | T101N | F102S | I126V | E173K | A202S | A255T | % Freq | CORP | |
|---|---|---|---|---|---|---|---|---|---|---|
| 1 | M | E | T | F | I | E | A | A | 72.20 | 0.144 |
| 2 | M | E | T | F | V | E | S | T | 19.97 | 0.144 |
| 3 | M | E | T | F | V | E | S | A | 2.92 | 0.144 |
| 4 | M | D | T | F | I | E | A | A | 2.00 | 0.144 |
| 5 | M | E | T | F | V | K | S | A | 1.15 | 0.144 |
| 6 | I | E | T | F | I | E | A | A | 0.46 | 1.200 |
| 7 | M | E | T | S | V | E | A | A | 0.38 | 0.144 |
| 8 | M | E | N | F | I | E | A | A | 0.31 | 0.144 |
| 9 | M | E | T | F | I | E | S | A | 0.23 | 0.144 |
| 10 | M | E | T | F | V | E | A | A | 0.15 | 0.144 |
| 11 | M | E | T | F | V | K | A | A | 0.08 | 0.144 |
| 12 | M | E | T | F | I | E | S | T | 0.08 | 0.144 |
| 13 | M | E | T | S | V | E | A | T | 0.08 | 0.144 |
AceView Gene Models
The information is based on AceView gene models, constructed from cDNA sequences. The information might be incomplete.
| Accession | Type | Chr | Start | End | Strand | |
|---|---|---|---|---|---|---|
| OR2A5.aApr07-unspliced | main_exon | CDS | chr7 | 144,050,402 | 144,051,334 | + |
| 3UTR | chr7 | 144,051,334 | 144,051,337 | + | ||