OR6C76 Olfactory Receptor
| Gene Symbol | OR6C761 (View this gene in GeneCards) |
| Family | 6 |
| Subfamily | C |
| Pseudogene | No |
| CORP pseudogene probability score | 0.65 (pseudogene) |
| Aliases | HsOR12.5.18 |
| External Ids | HGNC: 31305 GeneBank: NM_001005183 |
| Build #39 labels | |
| Chromosomal location | 12:55,426,254-55,427,189 (+) |
| Cluster | 12@56 |
| Synteny | CLIC#31 |
| Remarks |
Most Similar ORs in Humans (Paralogs)
| Symbol | Percent | Length |
|---|---|---|
| OR6C65 | 74.36% | 312 |
| OR6C66P | 77.42% | 310 |
| OR6C74 | 73.53% | 306 |
Most Similar ORs in other species (Orthologs)
| Specie | Symbol | Percent | Length |
|---|---|---|---|
| Dog | OR6C76P | 84% | 309 |
| Mouse | Or6c76 | 89% | 305 |
| Mouse | Or6c76b | 87% | 305 |
| Rat | Or6c76b | 88% | 305 |
| Rat | Or6c76-ps | 86% | 305 |
| Cow | OR6C296P | 78% | 308 |
| Orang | OR6C76P | 96% | 311 |
| Horse | OR6C66 | 77% | 310 |
| Chimp | OR6C74 | 73% | 307 |
Sequence information
| Nucleotide sequence |
ATGAAAAATAGAACATCAGTGACAGATTTCATCCTTCTGGGTCTGACGGATAATCCGCAA CTGCAGGTTGTGATTTTCTCGTTCCTATTTCTTACGTATGTACTGAGTGTTACTGGAAAT CTAACTATCATCTCCCTTACCCTGCTGGATTCCCACCTGAAGACCCCCATGTATTTCTTC CTCAGGAATTTCTCCTTGGAAATTTCATTTACTTCTGTCTGTAATCCTAGATTTCTGATC AGCATTCTAACAGGGGACAAATCCATATCTTATAATGCTTGTGCAGCTCAGCTATTTTTC TTTATCTTCCTTGGCTCAACGGAGTTTTTCCTCCTGGCCTCTATGTCCTATGATTGCTAT GTGGCTATATGTAAGCCTCTGCATTATACAACCATCATGAGTGACAGGATCTGTTATCAG CTTATAATCAGCTCTTGGCTGGCTGGTTTCTTGGTAATTTTTCCACCACTGGCCATGGGC TTACAGCTGGATTTCTGTGACTCCAATGTCATTGACCACTTTACCTGTGACTCTGCTCCT TTGCTGCAAATCTCTTGCACAGACACAAGTACTCTAGAGCTCATGAGCTTTATTTTAGCT CTGTTTACTCTTATATCCACTTTGATATTAGTAATTCTCTCCTATACTTACATCATCAGA ACTATTCTGAGAATCCCCTCAGCACAGCAAAGAAAAAAAGCCTTTTCAACCTGCTCCTCA CATGTGATTGTTGTCTCTATCTCTTATGGAAGCTGCATCTTCATGTATGTGAAAACATCA GCAAAGGAAGGAGTTGCTTTGACAAAAGGAGTAGCTATACTCAATACCTCTGTCGCTCCT ATGCTGAATCCATTTATTTACACTCTAAGAAACCAGCAGGTGAAACAAGCATTTAAGGAT GTTCTGAGAAAGATTTCCCACAAAAAAAAAAAACAC |
| Conceptual translation |
MKNRTSVTDFILLGLTDNPQLQVVIFSFLFLTYVLSVTGNLTIISLTLLDSHLKTPMYFF LRNFSLEISFTSVCNPRFLISILTGDKSISYNACAAQLFFFIFLGSTEFFLLASMSYDCY VAICKPLHYTTIMSDRICYQLIISSWLAGFLVIFPPLAMGLQLDFCDSNVIDHFTCDSAP LLQISCTDTSTLELMSFILALFTLISTLILVILSYTYIIRTILRIPSAQQRKKAFSTCSS HVIVVSISYGSCIFMYVKTSAKEGVALTKGVAILNTSVAPMLNPFIYTLRNQQVKQAFKD VLRKISHKKKKH Protein domains and features |
Variations - SNPs
| Chr | Start | End | Type | Variation | AA Change | SNP IDs |
|---|---|---|---|---|---|---|
| 12 | 100 | -100 | NS | G/A | V/I | 1000GP (YRI, YRI, YRI, YRI) |
| 12 | 100 | -100 | SYN | G/A | T/T | 1000GP (YRI, YRI, YRI, YRI, YRI) |
| 12 | 55,426,337 | 55,426,337 | SYN | C/T | F/F | 1000GP (CEU, CHBJPT) |
| 12 | 55,426,418 | 55,426,418 | SYN | C/T | T/T | 1000GP (CEU) |
| 12 | 55,820,104 | 55,820,104 | NS | A/G | I/V | rs74092309 (DbSNP) |
| 12 | 55,820,121 | 55,820,121 | SYN | C/T | F/F | rs6581046 (DbSNP) |
| 12 | 55,820,194 | 55,820,194 | SYN | C/T | L/L | rs74092310 (DbSNP) |
| 12 | 55,820,358 | 55,820,358 | SYN | A/G | T/T | rs12322458 (DbSNP) |
| 12 | 55,820,904 | 55,820,903 | Ins(1) | -/T | rs58396798 (DbSNP) | |
| 12 | 55,820,927 | 55,820,927 | NS | C/T | A/V | rs73327795 (DbSNP) |
| 12 | 55,820,959 | 55,820,959 | Del(1) | -/A | rs67035246 (DbSNP) | |
| 12 | 55,820,970 | 55,820,970 | Del(1) | -/A | rs57387180 (DbSNP) |
Variations - CNVs
| Chr | Start | End | Type | Sources |
|---|---|---|---|---|
| 12 | 55,819,938 | 55,822,973 | Deletion | #236 (Waszak) |
Haplotypes
Protein haplotypes were calculated using the 1000 genomes project as described in Olender T. et. al. BMC Genomics 2012.
| V23I | I80M | T107M | A158T | R224G | A297V | % Freq | CORP | |
|---|---|---|---|---|---|---|---|---|
| 1 | V | I | T | A | R | A | 89.93 | 0.729 |
| 2 | V | I | T | A | R | V | 3.28 | 0.729 |
| 3 | V | I | M | A | R | A | 2.19 | 0.729 |
| 4 | I | I | T | A | R | A | 1.97 | 0.729 |
| 5 | V | I | T | T | R | A | 1.42 | 0.729 |
| 6 | V | I | T | A | G | A | 0.88 | 0.729 |
| 7 | V | M | T | A | R | A | 0.33 | 0.729 |
AceView Gene Models
The information is based on AceView gene models, constructed from cDNA sequences. The information might be incomplete.
| Accession | Type | Chr | Start | End | Strand | |
|---|---|---|---|---|---|---|
| OR6C76.aApr07-unspliced | main_exon | CDS | chr12 | 55,426,254 | 55,427,189 | + |
| 3UTR | chr12 | 55,427,189 | 55,427,192 | + | ||