OR2K2 Olfactory Receptor
| Gene Symbol | OR2K21 (View this gene in GeneCards) |
| Family | 2 |
| Subfamily | K |
| Pseudogene | No |
| CORP pseudogene probability score | 0.12 (functional) |
| Aliases | HSHTPCRH06, OR9-17, HsOR9.5.1, ORL3221 |
| External Ids | HGNC: 8264 GeneBank: AB065707, BK004277, HSHTPRH06, NM_205859 ORDB: ORL3221 |
| Build #39 labels | OR2K2, OR2AR1P |
| Chromosomal location | 9:111,327,486-111,328,433 (-) |
| Cluster | 9@114 |
| Synteny | CLIC#20 |
| Remarks |
Most Similar ORs in Humans (Paralogs)
| Symbol | Percent | Length |
|---|---|---|
| OR13D1 | 62.21% | 307 |
| OR13D2P | 61.15% | 296 |
| OR13F1 | 65.12% | 301 |
Most Similar ORs in other species (Orthologs)
| Specie | Symbol | Percent | Length |
|---|---|---|---|
| Dog | OR13F1 | 67% | 305 |
| Mouse | Or2k2 | 88% | 309 |
| Rat | Or2k2 | 87% | 309 |
| Cow | OR13F1 | 65% | 305 |
| Orang | OR2K2P | 93% | 315 |
| Horse | OR13F1D | 67% | 305 |
| Chimp | OR13F1 | 67% | 305 |
Expression evidences
| Source | Accession |
|---|---|
| ESTs | DT932712 |
| mRNA | X64977 |
| GNF Atlas2 | gnf1h05181_at |
| GNF Atlas2 | gnf1h11034_s_at |
Sequence information
| Nucleotide sequence |
ATGCAAGGAGAAAACTTCACCATTTGGAGCATTTTTTTCTTGGAGGGATTTTCCCAGTAC CCAGGGTTAGAAGTGGTTCTCTTCGTCTTCAGCCTTGTAATGTATCTGACAACGCTCTTG GGCAACAGCACTCTTATTTTGATCACTATCCTAGATTCACGCCTTAAAACCCCCATGTAC TTATTCCTTGGAAATCTCTCTTTCATGGATATTTGTTACACATCTGCCTCTGTTCCTACT TTGCTGGTGAACTTGCTGTCATCCCAGAAAACCATTATCTTTTCTGGGTGTGCTGTACAG ATGTATCTGTCCCTTGCCATGGGCTCCACAGAGTGTGTGCTCCTGGCCGTGATGGCATAT GACCGTTATGTGGCCATTTGTAACCCGCTGAGATACTCCATCATCATGAACAGGTGCGTC TGTGCACGGATGGCTACGGTCTCCTGGGTGACGGGTTGCCTGACCGCTCTGCTGGAAACC AGTTTTGCCCTGCAGATACCCCTCTGTGGGAATCTCATCGATCACTTCACGTGTGAAATT CTGGCGGTGCTAAAGTTAGCTTGCACAAGTTCACTGCTCATGAACACCATCATGCTGGTG GTCAGCATTCTCCTCTTGCCAATTCCAATGCTCTTAGTTTGCATCTCTTACATCTTCATC CTTTCCACTATTCTGAGAATCACCTCAGCAGAGGGAAGAAACAAGGCTTTTTCTACCTGT GGTGCCCATTTGACTGTGGTGATTTTGTATTATGGGGCTGCCCTCTCTATGTACCTAAAG CCTTCTTCATCAAATGCACAAAAAATAGACAAAATCATCTCGTTGCTTTACGGAGTGCTT ACCCCTATGTTGAACCCCATAATTTACAGTTTAAGAAACAAGGAAGTCAAAGATGCTATG AAGAAATTGCTGGGCAAAATAACATTGCATCAAACACACGAACATCTC |
| Conceptual translation |
MQGENFTIWSIFFLEGFSQYPGLEVVLFVFSLVMYLTTLLGNSTLILITILDSRLKTPMY LFLGNLSFMDICYTSASVPTLLVNLLSSQKTIIFSGCAVQMYLSLAMGSTECVLLAVMAY DRYVAICNPLRYSIIMNRCVCARMATVSWVTGCLTALLETSFALQIPLCGNLIDHFTCEI LAVLKLACTSSLLMNTIMLVVSILLLPIPMLLVCISYIFILSTILRITSAEGRNKAFSTC GAHLTVVILYYGAALSMYLKPSSSNAQKIDKIISLLYGVLTPMLNPIIYSLRNKEVKDAM KKLLGKITLHQTHEHL Protein domains and features |
Variations - SNPs
| Chr | Start | End | Type | Variation | AA Change | SNP IDs |
|---|---|---|---|---|---|---|
| 9 | 114,090,277 | 114,090,277 | NS | A/G | M/T | rs73656223 (DbSNP) |
| 9 | 114,090,401 | 114,090,401 | NS | A/G | F/L | rs72763200 (DbSNP) |
| 9 | 114,089,896 | 114,089,896 | NS | A/T | I/N | rs13284539 (DbSNP) |
| 9 | 114,089,897 | 114,089,897 | NS | A/T | F/I | rs13285778 (DbSNP) |
| 9 | 114,090,629 | 114,090,629 | NS | C/T | V/I | rs73531578 (DbSNP) |
| 9 | 114,089,882 | 114,089,882 | NS | T/C | R/G | rs61748723 (DbSNP) |
| 9 | 114,090,279 | 114,090,279 | SYN | G/A | A/A | rs314452 (DbSNP) |
| 9 | 114,089,883 | 114,089,883 | SYN | G/A | Y/Y | rs61748722 (DbSNP) |
| 9 | 111,327,999 | 111,327,999 | SYN | A/G | A/A | 1000GP (CEU, CHBJPT) |
| 9 | 111,328,274 | 111,328,274 | NS | G/A | R/C | 1000GP (CEU) |
| 9 | 111,327,602 | 111,327,602 | NS | C/T | G/R | 1000GP (CEU, CHBJPT) |
| 9 | 100 | -100 | SYN | G/A | Y/Y | 1000GP (YRI, YRI) |
| 9 | 100 | -100 | NS | G/A | T/M | 1000GP (YRI, YRI) |
Variations - CNVs
| Chr | Start | End | Type | Sources |
|---|---|---|---|---|
| CopyNumber | 162 (Hasin) | |||
| 9 | 114,089,731 | 114,089,962 | Del(-22) | #5(modil) |
Haplotypes
Protein haplotypes were calculated using the 1000 genomes project as described in Olender T. et. al. BMC Genomics 2012.
| G278R | T177M | T146M | L55I | R54C | V29I | % Freq | CORP | |
|---|---|---|---|---|---|---|---|---|
| 1 | G | T | T | L | R | V | 88.79 | 0.281 |
| 2 | R | T | T | L | R | V | 9.06 | 0.281 |
| 3 | G | T | M | L | R | V | 1.08 | 0.281 |
| 4 | G | T | T | L | R | I | 0.77 | 0.281 |
| 5 | G | T | T | L | C | V | 0.15 | 0.281 |
| 6 | G | T | T | I | R | V | 0.08 | 0.675 |
| 7 | G | M | T | L | R | V | 0.08 | 0.281 |
AceView Gene Models
The information is based on AceView gene models, constructed from cDNA sequences. The information might be incomplete.
| Accession | Type | Chr | Start | End | Strand | |
|---|---|---|---|---|---|---|
| KIAA0368andOR2K2.cApr07 | main_exon | 3UTR | chr9 | 111,327,483 | 111,327,486 | - |
| CDS | chr9 | 111,327,486 | 111,328,433 | - | ||
| 5UTR | chr9 | 111,328,433 | 111,328,482 | - | ||
| exon_5UTR | chr9 | 111,330,106 | 111,330,224 | - | ||
| exon_5UTR | chr9 | 111,363,588 | 111,363,659 | - | ||
| exon_5UTR | chr9 | 111,366,239 | 111,366,286 | - | ||