OR2L8 Olfactory Receptor
| Gene Symbol | OR2L81 (View this gene in GeneCards) |
| Family | 2 |
| Subfamily | L |
| Pseudogene | No |
| CORP pseudogene probability score | |
| Aliases | OR1-46, HsOR1.5.18, ORL3015, ORL3017 |
| External Ids | HGNC: 15014 GeneBank: AB065627, BK004459, NM_001001963 ORDB: ORL3015, ORL3017 |
| Build #39 labels | OR2L8 |
| Chromosomal location | 1:247,948,858-247,949,793 (+) |
| Cluster | 1@248 |
| Synteny | CLIC#5 |
| Remarks | Segregating Pseudo Gene, a nonsynonymous SNP in a highly conserved amino-acid (rs4925583) |
Most Similar ORs in Humans (Paralogs)
| Symbol | Percent | Length |
|---|---|---|
| OR2L3 | 95.51% | 312 |
| OR2L6P | 92.63% | 312 |
Most Similar ORs in other species (Orthologs)
| Specie | Symbol | Percent | Length |
|---|---|---|---|
| Dog | OR2L3B | 82% | 312 |
| Dog | OR2L5 | 82% | 312 |
| Dog | OR2L5C | 82% | 312 |
| Mouse | Or2l5 | 79% | 312 |
| Rat | Or2l5b | 79% | 312 |
| Cow | OR2L3 | 85% | 312 |
| Cow | OR2L3C | 82% | 312 |
| Orang | OR2L3 | 95% | 312 |
| Horse | OR2L5JP | 85% | 312 |
| Horse | OR2L5 | 86% | 307 |
| Horse | OR2L5D | 84% | 307 |
| Horse | OR2L3GP | 82% | 311 |
| Chimp | OR2L3C | 97% | 312 |
| Chimp | OR2L3 | 97% | 312 |
| Chimp | OR2L6 | 94% | 312 |
Expression evidences
| Source | Accession |
|---|---|
| mRNA | BC140751 |
Sequence information
| Nucleotide sequence |
ATGGAAAATTACAATCAAACATCAACTGATTTCATCTTATTGGGGCTGTTTCCACCATCA AGAATTGACCTTTTCTTCTTCATTCTCATTGTTTTCATTTTCCTGATGGCTCTAATTGGA AACCTGTCCATGATTCTTCTCATCTTCTTGGACACCCATCTCCACACACCCATGTATTTC CTACTGAGTCAGCTCTCCCTCATTGACCTAAATTACATCTCCACCATTGTTCCTAAGATG GCATCTGATTTTCTGCATGGAAACAAGTCTATCTCCTTCACTGGGTGTGGGATTCAGAGT TTCTTCTTCTTGGCATTAGGAGGTGCAGAAGCACTACTTTTGGCATCTATGGCCTATGAT CGTTACATTGCTATTTGCTTTCCTCTCCACTATCTCATCCGCATGAGCAAAAGAGTGTGT GTGCTGATGATAACAGGGTCTTGGATCATAGGCTCGATCAATGCTTGTGCTCACACTGTA TATGTACTCCATATTCCTTATTGCCGATCCAGGGCCATCAATCATTTCTTCTGTGATGTC CCAGCAATGGTGACTCTGGCCTGCATGGACACCTGGGTCTATGAGGGCACAGTGTTTTTG AGTGCCACCATCTTTCTCGTGTTTCCCTTCATTGGTATTTCATGTTCCTATGGCCAGGTT CTCTTTGCTGTCTACCACATGAAATCTGCAGAAGGGAGGAAGAAAGCCTATTTGACCTGC AGCACCCACCTCACTGTAGTAACTTTCTACTATGCACCTTTTGTCTACACTTATCTACGT CCAAGATCCCTGCGATCTCCAACAGAGGACAAGGTTCTGGCTGTCTTCTACACCATCCTC ACCCCAATGCTCAACCCCATCATCTATAGCCTGAGGAACAAGGAGGTGATGGGGGCCCTG ACACGAGTGAGTCAGAGAATCTGCTCTGTGAAAATG |
| Conceptual translation |
MENYNQTSTDFILLGLFPPSRIDLFFFILIVFIFLMALIGNLSMILLIFLDTHLHTPMYF LLSQLSLIDLNYISTIVPKMASDFLHGNKSISFTGCGIQSFFFLALGGAEALLLASMAYD RYIAICFPLHYLIRMSKRVCVLMITGSWIIGSINACAHTVYVLHIPYCRSRAINHFFCDV PAMVTLACMDTWVYEGTVFLSATIFLVFPFIGISCSYGQVLFAVYHMKSAEGRKKAYLTC STHLTVVTFYYAPFVYTYLRPRSLRSPTEDKVLAVFYTILTPMLNPIIYSLRNKEVMGAL TRVSQRICSVKM Protein domains and features |
Variations - SNPs
| Chr | Start | End | Type | Variation | AA Change | SNP IDs |
|---|---|---|---|---|---|---|
| 1 | 100 | -100 | NS | T/G | S/A | 1000GP (YRI, YRI) |
| 1 | 100 | -100 | SYN | C/G | S/S | 1000GP (YRI, YRI) |
| 1 | 247,949,507 | 247,949,507 | NS | A/G | Y/C | 1000GP (CEU, CHBJPT) |
| 1 | 247,949,534 | 247,949,534 | NS | A/G | H/R | 1000GP (CEU, CHBJPT) |
| 1 | 248,112,560 | 248,112,560 | NS | A/G | H/R | rs57818366 (DbSNP) |
| 1 | 248,112,627 | 248,112,627 | SYN | C/T | C/C | rs4925787 (DbSNP) |
| 1 | 248,112,738 | 248,112,738 | SYN | A/C | V/V | rs60155834 (DbSNP) |
| 1 | 248,112,745 | 248,112,745 | NS | G/T | G/C | rs4925788 (DbSNP) |
| 1 | 248,112,762 | 248,112,762 | SYN | C/T | S/S | rs4925789 (DbSNP) |
| 1 | 248,112,762 | 248,112,763 | mnp | CA/TG | rs34851853 (DbSNP) | |
| 1 | 248,112,763 | 248,112,763 | NS | A/G | T/A | rs4925790 (DbSNP) |
| 1 | 248,112,771 | 248,112,771 | SYN | C/T | I/I | rs4925791 (DbSNP) |
| 1 | 248,112,781 | 248,112,781 | Del(1) | -/T | rs11284294 (DbSNP) | |
| 1 | 248,112,809 | 248,112,809 | NS | A/G | Y/C | rs4925583 (DbSNP) |
| 1 | 248,112,836 | 248,112,836 | NS | A/G | H/R | rs4925792 (DbSNP) |
| 1 | 248,112,915 | 248,112,915 | SYN | A/G | A/A | rs10888280 (DbSNP) |
| 1 | 248,113,026 | 248,113,026 | nonsense SNP | A/T | */Y | rs10888281 (DbSNP) |
| 1 | 248,113,040 | 248,113,040 | NS | A/G | K/R | rs10888282 (DbSNP) |
| 1 | 248,113,061 | 248,113,061 | NS | A/C | K/T | rs74155337 (DbSNP) |
Variations - CNVs
| Chr | Start | End | Type | Sources |
|---|---|---|---|---|
| 1 | 247,074,430 | 248,328,835 | CopyNumber | Variation_6816 (DGV) |
| 1 | 247,714,585 | 248,277,146 | CopyNumber | Variation_3339 (DGV) |
| 1 | 247,753,207 | 248,376,070 | CopyNumber | Variation_8353 (DGV) |
| 1 | 247,753,334 | 248,322,316 | CopyNumber | Variation_2358 (DGV) |
| 1 | 247,849,473 | 248,277,638 | CopyNumber | Variation_48302 (DGV) |
| 1 | 247,849,473 | 248,285,441 | CopyNumber | Variation_48303 (DGV) |
| 1 | 248,060,959 | 249,167,690 | CopyNumber | Variation_8354 (DGV) |
Haplotypes
Protein haplotypes were calculated using the 1000 genomes project as described in Olender T. et. al. BMC Genomics 2012.
| R134H | G196C | A202T | S214A | Y217C | H226R | C240S | % Freq | CORP | |
|---|---|---|---|---|---|---|---|---|---|
| 1 | R | C | T | S | C | R | C | 58.45 | 1.000 |
| 2 | R | G | A | S | Y | H | C | 20.28 | 0.030 |
| 3 | R | C | A | S | C | R | C | 9.22 | 1.000 |
| 4 | R | G | A | S | C | R | C | 4.30 | 1.000 |
| 5 | R | C | A | S | Y | H | C | 3.23 | 0.030 |
| 6 | H | C | T | S | Y | H | C | 1.00 | 0.030 |
| 7 | R | C | A | A | Y | R | C | 0.84 | 0.030 |
| 8 | R | G | A | A | Y | H | C | 0.61 | 0.030 |
| 9 | R | C | A | A | Y | H | C | 0.38 | 0.030 |
| 10 | R | C | T | A | Y | H | C | 0.31 | 0.030 |
| 11 | R | C | A | S | Y | R | C | 0.31 | 0.030 |
| 12 | R | C | T | S | C | H | C | 0.31 | 1.000 |
| 13 | R | G | A | S | Y | H | S | 0.15 | 0.088 |
| 14 | R | C | A | A | C | H | C | 0.08 | 1.000 |
| 15 | R | C | T | A | Y | R | C | 0.08 | 0.030 |
| 16 | R | G | A | A | C | R | C | 0.08 | 1.000 |
| 17 | R | G | A | A | C | H | C | 0.08 | 1.000 |
| 18 | R | C | A | A | C | R | C | 0.08 | 1.000 |
| 19 | R | G | T | S | C | R | C | 0.08 | 1.000 |
| 20 | R | C | A | S | C | H | C | 0.08 | 1.000 |
| 21 | R | G | A | A | Y | R | C | 0.08 | 0.030 |
AceView Gene Models
The information is based on AceView gene models, constructed from cDNA sequences. The information might be incomplete.
| Accession | Type | Chr | Start | End | Strand | |
|---|---|---|---|---|---|---|
| OR2L8.aApr07-unspliced | main_exon | CDS | chr1 | 247,948,858 | 247,949,793 | + |
| 3UTR | chr1 | 247,949,793 | 247,949,796 | + | ||