OR52N4 Olfactory Receptor
| Gene Symbol | OR52N41 (View this gene in GeneCards) |
| Family | 52 |
| Subfamily | N |
| Pseudogene | No |
| CORP pseudogene probability score | 0.04 (functional) |
| Aliases | OR11-64, HsOR11.3.78, ORL3297 |
| External Ids | HGNC: 15230 GeneBank: AB065813, BK004385, NM_001005175 ORDB: ORL3297 |
| Build #39 labels | OR52N4 |
| Chromosomal location | 11:5,754,741-5,755,703 (+) |
| Cluster | 11@6 |
| Synteny | CLIC#23 |
| Remarks | Segregating Pseudo Gene, a nonsynonymous SNP rs4910844 (AA change=R/* ) |
Most Similar ORs in Humans (Paralogs)
| Symbol | Percent | Length |
|---|---|---|
| OR52N1 | 73.33% | 315 |
| OR52N2 | 72.7% | 315 |
| OR52N5 | 70.16% | 305 |
Most Similar ORs in other species (Orthologs)
| Specie | Symbol | Percent | Length |
|---|---|---|---|
| Dog | OR52N4F | 85% | 321 |
| Dog | OR52N4G | 83% | 320 |
| Mouse | Or52n4 | 88% | 321 |
| Rat | Or52n4 | 88% | 321 |
| Rat | Or52n4c | 87% | 321 |
| Cow | OR52N4F | 85% | 321 |
| Cow | OR52N4H | 82% | 319 |
| Orang | OR52N1 | 74% | 314 |
| Horse | OR52N4J | 85% | 321 |
| Chimp | OR52N1 | 75% | 314 |
Expression evidences
| Source | Accession |
|---|---|
| mRNA | BC137036 |
Sequence information
| Nucleotide sequence |
ATGCTAACACTGAATAAAACAGACCTAATACCAGCTTCATTTATTCTGAATGGAGTCCCA GGACTGGAAGACACACAACTCTGGATTTCCTTCCCATTCTGCTCTATGTATGTTGTGGCT ATGGTAGGGAATTGTGGACTCCTCTACCTCATTCACTATGAGGATGCCCTGCACAAACCC ATGTACTACTTCTTGGCCATGCTTTCCTTTACTGACCTTGTTATGTGCTCTAGTACAATC CCTAAAGCCCTCTGCATCTTCTGGTTTCATCTCAAGGACATTGGATTTGATGAATGCCTT GTCCAGATGTTCTTCACCCACACCTTCACAGGGATGGAGTCTGGGGTGCTTATGCTTATG GCCCTGGATCGCTATGTGGCCATCTGCTACCCCTTACGCTATTCAACTATCCTCACCAAT CCTGTAATTGCAAAGGTTGGGACTGCCACCTTCCTGAGAGGGGTATTACTCATTATTCCC TTTACTTTCCTCACCAAGCTCCTGCCCTACTGCAGAGGCAATATACTTCCCCATACCTAC TGTGACCACATGTCTGTAGCCAAATTGTCCTGTGGTAATGTCAAGGTCAATGCCATCTAT GGTCTGATGGTTGCCCTCCTGATTTGGGGCTTTGACATACTGTGTATCACCAACTCCTAT ACCATGATTCTCCGGGCAGTGGTCAGCCTCTCCTCAGCAGATGCTCGGCAGAAGGCCTTT AATACCTGCACTGCCCACATTTGTGCCATTGTTTTCTCCTATACTCCAGCTTTCTTCTCC TTCTTTTCCCACCGCTTTGGGGAACACATAATCCCCCCTTCTTGCCACATCATTGTAGCC AATATTTATCTGCTCCTACCACCCACTATGAACCCTATTGTCTATGGGGTGAAAACCAAA CAGATACGAGACTGTGTCATAAGGATCCTTTCAGGTTCTAAGGATACCAAATCCTACAGC ATG |
| Conceptual translation |
MLTLNKTDLIPASFILNGVPGLEDTQLWISFPFCSMYVVAMVGNCGLLYLIHYEDALHKP MYYFLAMLSFTDLVMCSSTIPKALCIFWFHLKDIGFDECLVQMFFTHTFTGMESGVLMLM ALDRYVAICYPLRYSTILTNPVIAKVGTATFLRGVLLIIPFTFLTKLLPYCRGNILPHTY CDHMSVAKLSCGNVKVNAIYGLMVALLIWGFDILCITNSYTMILRAVVSLSSADARQKAF NTCTAHICAIVFSYTPAFFSFFSHRFGEHIIPPSCHIIVANIYLLLPPTMNPIVYGVKTK QIRDCVIRILSGSKDTKSYSM Protein domains and features |
Variations - SNPs
| Chr | Start | End | Type | Variation | AA Change | SNP IDs |
|---|---|---|---|---|---|---|
| 11 | 5,776,484 | 5,776,484 | nonsense SNP | A/T | R/* | rs4910844 (DbSNP) |
| 11 | 5,776,623 | 5,776,623 | NS | A/T | N/I | rs7396938 (DbSNP) |
| 11 | 5,776,287 | 5,776,287 | NS | C/T | T/I | rs7936512 (DbSNP) |
| 11 | 5,776,779 | 5,776,779 | NS | C/T | T/I | rs73406197 (DbSNP) |
| 11 | 5,776,470 | 5,776,470 | NS | G/T | R/L | rs7394584 (DbSNP) |
| 11 | 5,776,595 | 5,776,595 | NS | G/T | G/W | rs12363178 (DbSNP) |
| 11 | 5,755,254 | 5,755,254 | nonsense SNP | A/T | R/* | 1000GP (CEU, CHBJPT) |
| 11 | 5,755,365 | 5,755,365 | NS | T/G | W/G | 1000GP (CEU, CHBJPT) |
| 11 | 5,755,393 | 5,755,393 | NS | A/T | N/I | 1000GP (CEU, CHBJPT) |
| 11 | 5,755,057 | 5,755,057 | NS | C/T | T/I | 1000GP (CEU, CHBJPT) |
| 11 | 5,755,240 | 5,755,240 | NS | T/G | L/R | 1000GP (CEU, CHBJPT) |
| 11 | 5,755,249 | 5,755,249 | NS | A/C | Y/S | 1000GP (CEU, CHBJPT) |
| 11 | 5,755,697 | 5,755,697 | SYN | C/T | Y/Y | 1000GP (CEU) |
| 11 | 100 | -100 | NS | C/T | T/I | 1000GP (YRI, YRI, YRI, YRI, YRI) |
| 11 | 100 | -100 | nonsense SNP | A/T | R/* | 1000GP (YRI) |
Variations - CNVs
| Chr | Start | End | Type | Sources |
|---|---|---|---|---|
| 11 | 5,776,623 | 5,842,356 | CopyNumber | Variation_2902 (DGV) |
| 11 | 5,730,377 | 5,970,717 | CopyNumber | Variation_3836 (DGV) |
| 11 | 5,770,370 | 5,784,484 | CopyNumber | Variation_6925 (DGV) |
| 11 | 5,505,764 | 6,194,475 | CopyNumber | Variation_34458 (DGV) |
Haplotypes
Protein haplotypes were calculated using the 1000 genomes project as described in Olender T. et. al. BMC Genomics 2012.
| G95R | D123A | L167R | Y170S | R172* | N218I | I270T | N281S | S318Y | % Freq | CORP | |
|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | G | D | R | Y | R | I | I | N | S | 61.83 | 0.052 |
| 2 | G | D | R | Y | * | I | I | N | S | 20.28 | 1.200 |
| 3 | G | D | L | Y | R | N | I | N | S | 9.37 | 0.052 |
| 4 | G | D | R | Y | R | I | T | N | S | 4.53 | 0.052 |
| 5 | G | D | R | S | R | I | I | N | S | 1.92 | 0.181 |
| 6 | G | A | R | Y | R | I | I | N | S | 0.77 | 1.000 |
| 7 | G | D | R | Y | R | I | I | S | S | 0.61 | 0.052 |
| 8 | G | D | L | Y | R | I | I | N | S | 0.46 | 0.052 |
| 9 | R | D | R | Y | R | I | I | N | Y | 0.15 | 0.052 |
| 10 | G | D | R | Y | R | N | I | N | S | 0.08 | 0.052 |
AceView Gene Models
The information is based on AceView gene models, constructed from cDNA sequences. The information might be incomplete.
| Accession | Type | Chr | Start | End | Strand | |
|---|---|---|---|---|---|---|
| OR52N4.aApr07-unspliced | main_exon | CDS | chr11 | 5,754,741 | 5,755,703 | + |
| 3UTR | chr11 | 5,755,703 | 5,755,706 | + | ||