OR6C6 Olfactory Receptor
| Gene Symbol | OR6C61 (View this gene in GeneCards) |
| Family | 6 |
| Subfamily | C |
| Pseudogene | No |
| CORP pseudogene probability score | 0.03 (functional) |
| Aliases | HsOR12.5.9 |
| External Ids | HGNC: 31293 GeneBank: NM_001005493 |
| Build #39 labels | |
| Chromosomal location | 12:55,294,291-55,295,232 (-) |
| Cluster | 12@56 |
| Synteny | CLIC#31 |
| Remarks |
Most Similar ORs in Humans (Paralogs)
| Symbol | Percent | Length |
|---|---|---|
| OR6C70 | 74.75% | 305 |
| OR6C72P | 75% | 312 |
| OR6C74 | 70.19% | 312 |
Most Similar ORs in other species (Orthologs)
| Specie | Symbol | Percent | Length |
|---|---|---|---|
| Dog | OR6C6J | 86% | 312 |
| Dog | OR6C6LP | 86% | 312 |
| Mouse | Or6c6 | 88% | 312 |
| Mouse | Or6c6c | 86% | 312 |
| Rat | Or6c6b | 86% | 312 |
| Rat | Or6c6g | 86% | 312 |
| Rat | Or6c6f | 86% | 312 |
| Rat | Or6c6i | 86% | 312 |
| Cow | OR6C75 | 71% | 305 |
| Orang | OR6C6P | 90% | 314 |
| Horse | OR6C72 | 83% | 303 |
| Chimp | OR6C74 | 70% | 312 |
Sequence information
| Nucleotide sequence |
ATGAAGAACAAATCAATGGAAATAGAGTTCATTCTCCTAGGATTGACAGATGACCCACAG TTGCAAATTGTGATTTTCCTGTTTCTATTTCTCAACTACACCTTGAGCCTGATGGGGAAC TTAATCATCATCATCCTCACCCTGCTGGATCCCCGGCTCAAGACGCCAATGTATTTCTTT CTCCGTAATTTCTCCTTTTTGGAAGTAATATTCACAACAGTGTGTATTCCTAGATTCTTG ATAACCATTGTGACTAGAGACAAAACCATTTCTTATAATAATTGTGCAACTCAATTATTT TTTATCCTTTTACCGGGAGTTACTGAGTTTTACCTCCTGGCTGCCATGTCCTATGACCGC TACGTTGCCATCTGCAAACCACTGCATTATCCAATCATTATGAGCAGCAAAGTCTGCTAC CAACTTGTACTTAGCTCTTGGGTAACTGGATTCTTAATCATATTTCCCCCATTGGTCATG GGACTCAAGCTGGATTTTTGTGCTTCCAAAACTATTGACCACTTTATGTGTGAAACTTCT CCTATTCTGCAGATCTCCTGCACAGATACCCATGTCCTAGAATTGATGTCTTTTACCTTA GCTGTGGTGACACTTGTGGTCACACTGGTATTAGTGATTCTCTCTTACACTTGCATTATT AAGACCATTCTGAAATTCTCTTCTGCACAGCAAAGGAACAAAGCATTTTCCACCTGTACT TCCCACATGATTGTTGTCTCCATGACATACGGTAGCTGTATCTTTATGTATATTAAACCA TCTGCAAAAGAAAGAGTGACTGTATCCAAAGGTGTAGCTTTGCTCTATACCTCAATTGCC CCTTTACTAAATCCCTTCATTTATACTCTCAGAAACCAGCAGGTGAAAGAAGTCTTCTGG GATGTATTACAAAAGAATTTGTGTTTTTCTAAAAGACCATTT |
| Conceptual translation |
MKNKSMEIEFILLGLTDDPQLQIVIFLFLFLNYTLSLMGNLIIIILTLLDPRLKTPMYFF LRNFSFLEVIFTTVCIPRFLITIVTRDKTISYNNCATQLFFILLPGVTEFYLLAAMSYDR YVAICKPLHYPIIMSSKVCYQLVLSSWVTGFLIIFPPLVMGLKLDFCASKTIDHFMCETS PILQISCTDTHVLELMSFTLAVVTLVVTLVLVILSYTCIIKTILKFSSAQQRNKAFSTCT SHMIVVSMTYGSCIFMYIKPSAKERVTVSKGVALLYTSIAPLLNPFIYTLRNQQVKEVFW DVLQKNLCFSKRPF Protein domains and features |
Variations - SNPs
| Chr | Start | End | Type | Variation | AA Change | SNP IDs |
|---|---|---|---|---|---|---|
| 12 | 100 | -100 | nonsense SNP | A/T | L/* | 1000GP (YRI) |
| 12 | 100 | -100 | NS | G/A | S/F | 1000GP (YRI, YRI, YRI, YRI) |
| 12 | 100 | -100 | SYN | G/A | Y/Y | 1000GP (YRI, YRI) |
| 12 | 55,294,483 | 55,294,483 | SYN | G/A | Y/Y | 1000GP (CEU, CHBJPT) |
| 12 | 55,295,033 | 55,295,033 | NS | A/G | L/S | 1000GP (CHBJPT) |
| 12 | 55,295,110 | 55,295,110 | NS | T/G | L/F | 1000GP (CEU) |
| 12 | 55,688,267 | 55,688,267 | SYN | A/G | Y/Y | rs7308594 (DbSNP) |
| 12 | 55,688,448 | 55,688,448 | NS | A/G | I/T | rs11171402 (DbSNP) |
| 12 | 55,688,815 | 55,688,814 | Ins(1) | -/C | rs35212493 (DbSNP) |
Haplotypes
Protein haplotypes were calculated using the 1000 genomes project as described in Olender T. et. al. BMC Genomics 2012.
| S269P | S227F | L200* | T190I | T188R | P105L | L67S | L41F | L41S | Q22P | % Freq | CORP | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | S | S | L | T | T | P | L | L | L | Q | 88.63 | 0.131 |
| 2 | S | S | L | I | T | P | L | L | L | Q | 4.45 | 0.131 |
| 3 | S | S | L | T | R | P | L | L | L | Q | 2.07 | 0.131 |
| 4 | S | S | L | T | R | L | L | L | L | P | 1.23 | 0.131 |
| 5 | S | S | L | T | T | P | L | L | S | Q | 1.23 | 0.131 |
| 6 | S | S | L | T | T | P | S | L | L | Q | 0.69 | 0.131 |
| 7 | S | S | * | T | T | P | L | L | L | Q | 0.54 | 1.200 |
| 8 | S | F | L | I | T | P | L | L | L | Q | 0.46 | 0.131 |
| 9 | S | S | L | T | T | P | L | F | L | Q | 0.38 | 0.131 |
| 10 | P | S | L | T | T | P | L | L | L | Q | 0.23 | 0.131 |
| 11 | S | S | * | T | R | P | L | L | L | Q | 0.08 | 1.200 |
AceView Gene Models
The information is based on AceView gene models, constructed from cDNA sequences. The information might be incomplete.
| Accession | Type | Chr | Start | End | Strand | |
|---|---|---|---|---|---|---|
| OR6C6.aApr07-unspliced | main_exon | 3UTR | chr12 | 55,294,288 | 55,294,291 | - |
| CDS | chr12 | 55,294,291 | 55,295,232 | - | ||